BRAVECTO® PLUS at a glance
Fast and easy-to-apply 12-week protection1
Immediate and persistent flea (Ctenocephalides felis) and tick (Ixodes ricinus) killing activity to 12 weeks
Prevents heartworm
disease caused by
Dirofilaria immitis*
*When administered repeatedly as indicated at 12-weeks intervals.
BRAVECTO® PLUS at a glance
Protection against aelurostrongylosis by preventing the establishment of adult aelurostrongylus abstrusus (lungworm) responsible for clinical disease.
Extended protection in just 1 dose makes on-time application simple
The survey has shown that cat owners are more likely to administer fluralaner at the recommended redosing interval compared to monthly products, indicating that
Less frequent redosing contributes to improved adherence2
Cat owner purchasing compliance is better with the extended flea and tick protection that Bravecto provides2. Fast, easy and lasting protection is the best way to achieve year-round coverage.
Reasons owners may not be protecting their cats from parasites:
- Treating cats can be difficult
- Do not understand or are not aware of the risks
- Forget to give the next dose
BRAVECTO PLUS: Convenient, broad-spectrum protection
BRAVECTO PLUS provides1
12 weeks flea and tick control
12 weeks heartworm disease prevention*
Ear mite treatment3
Broad-spectrum worm coverage
12 weeks Aelurostrongylosis (lungworm) prevention4
Reduced dosing frequency for improved adherence2
*When administered repeatedly as indicated at 12-week intervals.
Broad spectrum protection in just 1 dose
Break the flea life cycle with 12 weeks efficacy in one dose1
Efficacy against ticks over 12 weeks1
When administered repeatedly at a 12-week interval, BRAVECTO PLUS continuously prevents heartworm disease caused by Dirofilaria immitis1
Treatment of infections with intestinal roundworm (Toxocara cati; L4, L5 and adults). Treatment of infections with hookworm (Ancylostoma tubaeforme; immature adults and adults)1
100% treatment efficacy of ear mites (Otodectes cynotis)3
12 weeks preventiion of aelurostrongylosis by preventing the establishment of adult Aelurostrongylus abstrusus (lungworm) responsible for clinical disease4
More than just flea and tick protection
Fleas and ticks are vectors for many dangerous diseases3
BRAVECTO PLUS can be used as a treatment strategy for the control of flea allergy dermatitis (FAD).1
BRAVECTO PLUS protection against heartworm
INFECTION
with heartworm
treatment
REPEAT ADMINISTRATION EVERY 12 WEEKS
to continuously prevent heartworm disease
BRAVECTO PLUS offers an innovative approach to heartworm disease prevention with a combination of a 60-day “reach forward” effect that prevents the development of Dirofilaria immitis larvae AND a “reach back” effect, where heartworm larvae entering the cat in the 30 days prior to treatment are effectively removed.5
THE LEADING LONG-LASTING SYSTEMIC FLEA AND TICK PROTECTION
Learn how BRAVECTO PLUS outlasts monthly alternatives
Long-lasting protection with just one dose
One dose of BRAVECTO PLUS protects your patient against fleas, ticks and heartworms for 12 weeks.1 That’s year-round protection made easy, all backed up by the Big Flea and Tick Guarantee.
Kills fleas and ticks in hours
BRAVECTO PLUS kills fleas (Ctenocephalides felis) and ticks (Ixodes ricinus) within 48 hours.1
Also approved for kittens
BRAVECTO PLUS for cats is indicated for kittens over 9 weeks old and weighing at least 1.2 kg.1
Trusted by millions
Over 300 million doses of BRAVECTO have been distributed around the world.
Broad spectrum parasite protection
12 weeks heartworm disease prevention1,* 12 weeks aelurostrongylosis (lungworm) prevention.1 Treats Toxocara cati (intestinal roundworm) and Ancylostoma tubaeforme (hookworm) infections1.
*When administered repeatedly as indicated at 12-week intervals.
What does BRAVECTO PLUS DO for cats?
Just 1 dose of BRAVECTO PLUS protects your feline patients (and their homes) from the dangers posed by fleas and ticks continuously for 12 weeks.1
When administered repeatedly at a 12-week interval, BRAVECTO PLUS prevents heartworm disease caused by D immitis.1
BRAVECTO PLUS prevents aelurostrongylosis (by adult Aelurostrongylus abstrusus responsible for clinical disease) for up to 12 weeks.1,4
BRAVECTO PLUS also treats infections with Toxocara cati (intestinal roundworm) and Ancylostoma tubaeforme (hookworm).1
Broad spectrum and convenient year-round protection
Direct cat owners to give one dose of BRAVECTO PLUS for 12 weeks of lasting flea and tick protection. For heartworm treatment, direct cat owners to administer BRAVECTO PLUS at a 12-week interval. BRAVECTO PLUS provides 12 weeks protection against aelurostronglosis by preventing the establishment of adult Aelurostrongylus abstrusus (lungworm) responsible for clinical disease and can be used to treat infections with gastrointestinal nematodes.1
BRAVECTO IS HERE TO SUPPORT YOU ALL YEAR ROUND
We have tools to help you start the conversation with pet owners about why year-round protection may be necessary for their pet’s lifestyle
Discover tools that will help you engage and educate your pet owners.
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PRESCRIBING BRAVECTO PLUS
BRAVECTO PLUS is available for cats weighing 1.2 kg and more. The fumble-free Twist’n’Use™ applicator makes administration easy for pet owners. It’s straightforward and, most importantly, pet friendly. The cap does not come off to offer additional safety, leaving no small parts loose for animals or children to accidentally swallow.
FREQUENTLY ASKED QUESTIONS
The following frequently asked questions (FAQs) can help answer additional questions you may have.
Fluralaner is a potent inhibitor of arthropod nervous system function by acting antagonistically on ligand-gated chloride channels (GABA-receptor and glutamate-receptor). These are insect and acarine specific GABA-gated chloride channels (GABACI) and glutamate-gated chloride channels (GluCl). Fluralaner at expected clinical concentrations showed no activity on the mammalian nervous system GABACI receptor.6
[FPO: link to fluralaner MOA video (URL TBD)]
Moxidectin is a semisynthetic derivative of nemadectin, belonging to the milbemycin group of macrocyclic lactones (avermectins being the other). Milbemycins and avermectins have a common mode of action that is based on the binding of ligand-gated chloride channels (glutamate-R and GABA-R). This leads to an increased membrane permeability of nematode and arthropod nerve and/or muscle cells for chloride ions and results in hyperpolarisation, paralysis and death of the parasites. Binding of glutamate-gated chloride channels, which are specific to invertebrates and do not exist in mammals, is considered the main mechanism for the anthelmintic and insecticidal activity.
Yes, 9-week-old kittens were treated at doses of up to 465 mg fluralaner and 23.25 mg moxidectin/kg body weight with BRAVECTO spot-on for cats. No adverse reactions were observed following topical administration to kittens.1
Fluralaner and moxidectin, the active ingredients in BRAVECTO PLUS, are readily systemically absorbed from the application site. Fluralaner and moxidectin are mainly excreted unchanged in the faeces and to a very low extent in urine. The pharmacokinetic profiles of fluralaner and moxidectin are not affected by co-administration.1
BRAVECTO PLUS is licensed to be used year-round aligning with ESCCAP guidelines to worm cats at least quarterly against Toxocara roundworm.7
A growing kitten should be dosed with a pipette containing the amount of fluralaner and moxidectin appropriate to the body weight at the time of treatment. The field studies conducted in the EU and the US included growing kittens, and there was no evidence of lack of efficacy. BRAVECTO showed very good and continuous efficacy throughout the 12-week interval in these kittens.
BRAVECTO has a high margin of safety. In safety studies in cats, BRAVECTO PLUS (fluralaner + moxidectin) was tested in cats and kittens at up to 5x the recommended dose at 8-week intervals for 3 consecutive treatments. Therefore, adverse effects beyond those reported on the prescribing information are not expected if cats are inadvertently treated twice before the recommended re-treatment interval has elapsed.1
The onset of effect (killing effect) is within 48 hours for fleas and ticks (C felis and I ricinus).1
BRAVECTO first received regulatory approval in early 2016. It is backed by many clinical studies and over 80 published papers.
BRAVECTO kills fleas within 48 hours of administration. BRAVECTO kills fleas before they can lay eggs.1
BRAVECTO PLUS prevents heartworm disease caused by Dirofilaria immitis for up to 12 weeks when administered repeatedly at the indicated 12-week interval.1
BRAVECTO PLUS prevents aelurostrongylosis by preventing the establishment of adult Aelurostrongylus abstrusus (lungworm) responsible for clinical disease.1
REFERENCES
- BRAVECTO PLUS SPOT ON DATASHEET: https://www.noahcompendium.co.uk/?id=-469893&fromsearch=true#iosfirsthighlight
- Lavan, R., et al. (2020). “Adherence to veterinary recommendations for ectoparasiticides purchased by cat owners in the USA.” Parasit Vectors 13(1): 541.
- Taenzler, J., et al. (2018). “Efficacy of fluralaner plus moxidectin (BRAVECTO® PLUS spot-on solution for cats) against Otodectes cynotis infestations in cats.” Parasit Vectors 11(1): 595.
- Raue, K., et al. (2021). “Efficacy of Bravecto((R)) Plus spot-on solution for cats (280 mg/ml fluralaner and 14 mg/ml moxidectin) for the prevention of aelurostrongylosis in experimentally infected cats.” Parasit Vectors 14(1): 110.
- BRAVECTO PLUS. European Public Assessment Report, 2019. EMA/626816/2019
- Gassel, M., et al. (2014). “The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod gamma-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity.” Insect Biochem Mol Biol 45: 111-124.
- Control of Ectoparasites 3 in Dogs and Cats. ESCCAP Guideline 03 Seventh Edition – January 2022
Bravecto® Spot-on for Cats and Bravecto® Chewable Tablets, Spot-on for Dogs and Bravecto® 150 mg/ml powder and solvent for suspension for injection for dogs contain fluralaner. POM-V.
Bravecto® Plus Spot-on for Cats contains fluralaner and moxidectin. POM-V.
Further information is available from the SPC, Datasheet or package leaflet.
Advice should be sought from the medicine prescriber. Prescription decisions are for the person issuing the prescription alone.
Use Medicines Responsibly.
MSD Animal Health UK Limited. Registered office Walton Manor, Walton, Milton Keynes MK7 7AJ, UK. Registered in England & Wales no. 946942.
